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The market for biopharmaceuticals is continuously growing, especially in the commercialization of antibody drugs. This trend calls for the development of new process steps as well as the optimization of established processes. The purification development of complex molecules is considered the most cost- and time-intensive step due to high investment and material costs. Our objective is to establish the SpecPlate in as many process steps as possible to provide our clients with cost and time advantages. This innovative UV plate will set a new standard in UV/Vis spectroscopy.
My department is involved in investigating diverse facets of advanced downstream processes in the biopharmaceutical industry including protein purification, formulation, and analytics.
The measurement of absorption spectra in highly concentrated samples utilizing common methods exhibits limitations and errors. However, with the introduction of SpecPlate, these limitations are overcome, and existing benefits are combined to create an efficient plate-based absorption spectroscopy solution. The implementation of SpecPlate is straightforward, providing an alternative to conventional absorption spectroscopy methods. It is a novel technique which is an improved approach to the measurements of absorption spectra thus, highly recommended for researchers and industrialists working on high-concentration samples.
I am a Bioengineering scientist specializing in inter-disciplinary research aimed at elevating biopharmaceutical process development to new frontiers. I received my degree from the Karlsruhe Institute of Technology (KIT) where I focused my doctoral research on developing analytic methodologies for predicting protein solution stability. During this research, I worked with Carsten Radtke in creating and testing the first SpecPlate prototype.
In 2020, I joined the Technical University of Berlin to expand my knowledge in laboratory automation towards upstream process development. Currently, I lead a subgroup at KIWI-Biolabs where we explore the efficient integration of AI methods in bioprocess development.
I am convinced that only a holistic understanding of the biotechnological development pipeline can significantly accelerate biopharmaceutical processes and contribute to the faster and safer production of biopharmaceuticals.
During my time at KIT in the research group of Prof. Hubbuch, I conducted investigations towards linking microfluidic structures with pipetting robots. Thereafter, in collaboration with Marie-Therese Schermeyer, the concept of SpecPlate was developed. Our confidence in the SpecPlate technology drove us to seek realisation partners and form a strong alliance with innoME, or its business unit PHABIOC. Together, we developed SpecPlate, making plate-based absorption measurements more efficient and precise.
Should you have an inspiring project concept or desire to partner with Prof. Dr. Hubbuch or Frau Dr. Ing. Schermeyer, kindly reach out to Carsten Radtke via this email: carsten.radtke@phabioc.com.
Project launch in a ZIM cooperation project.
Translation:
Construction of first functional prototypes and feedback from field test customers.
2022 Start setting up the serial production.
Closed measuring chambers prevent meniscus formation and measurement errors.
Our 384 measuring chambers habe a standard layout which make them easy to integrate into the process.
Easy data evaluation with the help of the free evaluation software from PHABIOC.
The four chamber heights enable measurement in a wide range of concentrations, reducing the need for dilution series.
With only 96 pipetting steps, 384 measurement points can be obtained. The application of the slope method is possible.
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